In patients with APDS who experience disease progression2:

  • Inadequate control of immune deficiency can lead to infections, end-organ lung damage such as bronchiectasis, and lymphoma
  • Uncontrolled immune dysregulation may lead to lymphoproliferation including lymphadenopathy, splenomegaly, and potentially lymphoma
  • End-organ damage has frequently preceded a confirmed diagnosis of APDS13,16
    CMV, cytomegalovirus; EBV, Epstein-Barr virus; IgA, immunoglobulin A.